Minyak gandapura di reaksikan dengan naoh 6 m membentuk endapan berwarna putih. O c ch 3 c o o oh h h h h figure 1 acetylsalicylic acid aspirin, c9h8o4 aspirin acetylsalicylic acid is a versatile drug that is consumed in huge quantities worldwide. A history of aspirin infographic pharmaceutical journal. Effect of aspirin on disabilityfree survival in the healthy elderly pdf. This site uses cookies small files stored on your computer. The effect of aspirin on the periodontal parameter.
Sintesis metil asetilsalisilat dan metil benzoilsalisilat sebagai analog aspirin telah dilakukan dengan esterifikasi. It is commonly used as an analgesic, antipyretic and an antiinflammatory agent. Sulfanilamide inhibits the formation of folic acid in bacteria, thus. Aspirin is also recommended for treatment of rheumatoid arthritis, osteoarthritis and other rheumatoid diseases. Aspirinfree antithrombotic management following coronary stenting. Sulfa drugs were discovered in the early 1900s and found to be active antibacterial agents. Praktikum kimia organik laboratorium kimia organik program studi kimia fmipa itb.
Synthesis of ibuprofen in the introductory organic. It relieves your pain, reduces the inflammation swelling, and generally makes you feel better. The absence or presence of bleeding on probing bop is a sign of periodontal health or disease, but the presence of bop is not an accurate predictor of disease progression. Take a small amount of the aspirin tablet and dissolve as much as you can in 3 drops of ethyl acetate. Tampung hasil sintesis disimpan dalam wadah gelap, tertutup rapat dan terlindung cahaya matahari. Selain digunakan sebagai bahan utama pembuatan aspirin, asam salisilat. Pada orang usia lanjut efek samping diare hebat lebih sering dilaporkan. Sulfa antibiotics synthesis of sulfanilamide intoroduction many people think of the term chemotherapy as relating to specific modern drug treatments used to fight cancer. Sintesis, pencirian dan biopenggunaan shabir ahmad, hira rashid, qudisa jalil, sidra munir, barkatullah, sulaiman khan, riaz ullah, abdelaaty a. Antiplatelet antiaggregasi trombosit 1 aspirin obat ini menghambat sklooksigenase, dengan cara menurunkan sintesis atau infari lepasnya senyawa yang mendorong adhesi seperti thromboxane a2. Aspirin simple english wikipedia, the free encyclopedia.
Please ask your doctor or pharmacist if you are unsure how to take this medicine. Jun 04, 2015 sintesis asetanilida sebagai suatu amida adalah merupakan suatu reaksi substitusi nukleofilik sn asil addition elimination diantara anilin. Aspirin is one of the milder and least expensive pain relievers available. Pemberian aspirin dosis rendah 50150 mg bekerja pada enzim siklooksigenase, yakni dengan cara menekan sintesis tromboksan secara selektif dan tidak terlalu berpengaruh terhadap sintesis. Asam asetil salisilat yang biasa disebut aspirin, dapat digunakan sebagai obat analgesik, antipiretik, dan asnti rematik. Bayer bitterfeld gmbh, germany for bayer consumer care ag, basel, switzerland date of information.
To become familiar with the role of synthetic chemistry through the production of aspirin. Aspirin is one of the most widely used nonprescription drugs in the world, with over 50 million pounds consumed annually. Ies vicent castell i domenech analisis instrumental pnt 9pagina 1 ciclo formativo. Persamaan reaksi sintesis aspirin tersebut adalah sebagai berikut. Senyawa ini dapat disintesis di laboratorium dari asam salisilat. Capitals indicate lifethreatening, underlines indicate most frequent. Acetylsalicylic acid, synthesized in an industrial environment in 1897, was introduced to the market as aspirin in 1899. Acetylsalicylic acid aspirin, c9h8o4 aspirin acetylsalicylic acid is a versatile drug that is consumed in huge quantities worldwide. Always take aspirin c exactly as directed in the patient information leaet. Contoh industri asilasi adalah sintesis aspirin, di mana asam salisilat diasilasi oleh asetat anhidrida. Pada percobaan ini asam salisilat dibuat dari minyak gandapura dengan konsentrasi 100%. Effect of different nonsteroidal antiinflammatory drugs, aspirin. Penggunaan antiplatelet aspirin pada akut stroke iskemik. This otc medicine monograph outlines the requirements for australian market authorisation of tablets containing aspirin as a single active ingredient when applied for as an otc new medicine n2 application.
Penghambat enzim siklooksigenase terjadi karena aspirin mengasetilasi enzim tersebut. Sitokine, khususnya il6, akan mestimulasi pelepasan reaktan fase i seperti creactive protein crp. Berikut ini adalah download jurnal gratis yang merupakan kumpulan file dari berbagi sumber tentang sintesis aspirin pdf yang bisa bapakibu gunakan dan diunduh secara gratis dengan menekan tombol download biru dibawah ini. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever. Can reduce heart attack severity if taken at the very first sign. Esterification reaction synthesis of aspirin introduction aspirin is one of the milder and least expensive pain relievers available. All trademarks and s on this website are property of their respective owners. Aspirin adalah sebuah asam karboksilat, seperti juga asam oleat. If you have to follow a lowsalt diet, you should take this into account.
All of the reactions and techniques are a standard part of any introductory organic chemistry course. Hasil akhir reaksi tersebut mengandung empat produk utama dan 2,3dimetoksi54fenil1,3siklobutadienil benzofenon dihasilkan dengan rendemen sebesar 14,10%. At very low doses, aspirin is used to treat and prevent heart attacks and blood clots. Mulamula anilin bereaksi dengan asam asetat membentuk suatu amida dalam keadaan transisi, kemudian diikuti dengan. Tujuan percobaan memahami reaksi esterifikasi fenol memahami reaksi pembuatan aspirin mampu melakukan uji kadar aspirin hasil reaksi 2. Tinjauan pustaka esterifikasi adalah reaksi pengubahan dari suatu asam.
Doc laporan praktikum kimia organik sintesis aspirin. Anilin bersifat sebagai nukleofil, dan gugus asil dari asam asetat bersifat elektrofil. Nsaids, aspirin, nimesulide and celecoxib on the intesti nal brush border. Tujuan dari percobaan ini adalah sintesis asam salisilat dari minyak gandapura. Pada minyak gandapura terdapat metil salisilat yang merupakan bahan dasar sintesis pengawet bahan makanan dan bahan dasar pembuatan obat sakit kepala aspirin sebesar 9699%. Download retrosintesis aspirin document on this page you can read or download retrosintesis aspirin in pdf format. Tnfa dan il1 bertanggung jawab pada sintesis il6, il8, dan interferon gamma. It also has an antiplatelet effect it reduces the number of platelets in the blood which reduces blood clotting in that function it is used to prevent heart attacks. Synthesis of ibuprofen in the introductory organic laboratory. Pain relief and more chemsumer b ut before you settle into channel surfing, think about that bottle of aspirin or ibuprofen.
Sintesis asetanilida sebagai suatu amida adalah merupakan suatu. The use of aspirin in combination with a p2y12 receptor inhibitor, also known as dual antiplatelet therapy, is at the cornerstone of treatment. Apr 05, 2011 a method for the synthesis of ibuprofen in introductory organic chemistry laboratory courses is reported. What links here related changes upload file special pages permanent link page information wikidata item cite this page. In the first lab session, students reduce pisobutylacetophenone to an alcohol and then convert this alcohol to the corresponding chloride. Aspirin is also used longterm to help prevent further heart attacks, ischaemic strokes.
Aspirin continues to attract research and debate, 115 years after. Aspirin merupakan obat analgesik dan turunan dari asam salisilat. If you dont see any interesting for you, use our search form on bottom v. Selain itu juga untuk mensintesis polimer resin melalui senyawa antara asam salisilat asam2hidroksibenzoat. Sifat kimia yang paling menonjol dari asam karboksilat ialah keasamaanya. Actually, modern chemotherapy began in the early 1900s with the work of paul ehrlich, a german medical doctor and researcher, who is. Aspirin, also known as acetylsalicylic acid asa, is a medication used to treat pain, fever, or inflammation. Route onset peak duration aspirin pirin po 530min 1. Interleukin juga berfungsi langsung pada jaringan sehingga menyebabkan terjadinya rangkaian koagulasi,peepasan nitrik oxida, paf, prostaglandin, dan.
Aspirin is also recommended to sufferers of heart attack, ministroke and unstable angina. Polymers encapsulated aspirin loaded silver oxide nanoparticles. Pertama obat 4 dd 1 g parasetamol 4 kali sehari 1 gram parasetamol, bila efeknya kurang ke 46 dd kodein 3060 mg. Specific inflammatory conditions which aspirin is used to treat include kawasaki disease, pericarditis, and rheumatic fever. Synthesis, characterization and its bioapplications aspirin terkurung polimer dimuatkan nanozarah perak oksida. Piroksikam indikasi dari piroksikam yaitu rheumatoid arthritis. Sintesis turunan benzofenon melalui reaksi penataan ulang. Sulfanilamide if we have sufficient time this semester, you will have an opportunity to measure the antibiotic activity of sulfanilamide against selected strains of pathogenic bacteria. It is most commonly used as a pain killer, or to reduce fever or inflammation. Aspirinc is a white effervescent tablets with oneside bayercrossembossing. Drugs in early clinical development for the treatment of female sexual dysfunction. A method for the synthesis of ibuprofen in introductory organic chemistry laboratory courses is reported. Sesuai dengan reaksi dibawah, asam salisilat akan menjadi pereaksi pembatas. Sulfa antibiotics synthesis of sulfanilamide intoroduction.
Larutan dipanaskan agar endapan yang terbentuk melarut dengan alat yang bernama socklet. It is used to recover after cardiovascular surgery. Isolasi etil pmetoksisinamat dari kencur kaempferia galanga l. This figure mainly reflects purchase of 16,000 tons of aspirin tablets or 80 million tablets a year. Piroksikam indikasi dari piroksikam yaitu rheumatoid arthritis dan osteoarthritis sebagai anti inflamasi dan analgetik.
Aspirin umumnya digunakan untuk melepaskan sakit akibat rematik otot, sakit pinggang dan beberapa variasi radang lainnya seperti radang amandel, radang selaput lendir, sakit gigi dan sering digunakan untuk pengobatan arthritis serta insomnia. Acetylsalicylic acid asa aspirin is a commonly used. Tujuan percobaan untuk memberikan pengenalan tentang reaksi asetilasi terhadap gugus fenol. Dec 06, 2015 on this page you can read or download retrosintesis aspirin in pdf format. Pada wanita hamil asam mefenamat tidak dianjurkan digunakan selama 7 hari. Predisposing factors for ais are summarized in table 1. Do not lose this container or its contents, you will use them later. It is a nonsteroidal antiinflammatory drug nsaid with a wide range of physiological effects. Senyawa lain, misalnya asam asetil salisilat aspirin 5. You will perform standard zone of inhibition assays using filter paper discs impregnated with sulfanilamide and placed on lawns of growing bacteria. Aspirin, also known as acetylsalicylic acid asa, is a medication used to reduce pain, fever, or inflammation.
Aspirin was one of the first drugs to come into common usage and it still one of the most researched drugs in the world, with an estimated 700 to 1,000 clinical trials conducted each year. The effect of aspirin on the periodontal parameter bleeding on probing. Melaporkan dan menyerahkan hasil percobaan sintesis, yang ditempatkan dalam botol kecil lihat contoh yang bersih dan diberi label yang berisi nama, nim, kelompok, nama zat, beratnya dan data fisik. Ini dilaporkan sambil membawa buku catatan pengamatan, dan diketahui oleh asisten. The role of platelet and its interaction with aspirin scielo colombia. The handle holds various files of this leiden university. Synthesis of sulfanilamide from aniline williamson, k. This site uses cookies small files stored on your computer to simplify and improve your experience of this website.